Thr-Asp-F-amidine
Names
[ CAS No. ]:
1345019-64-8
[ Name ]:
Thr-Asp-F-amidine
[Synonym ]:
L-Ornithinamide, N-acetyl-L-threonyl-L-α-aspartyl-N5-(2-fluoro-1-iminoethyl)-
N-Acetyl-L-threonyl-L-α-aspartyl-N5-(2-fluoroethanimidoyl)-L-ornithinamide
Biological Activity
[Description]:
Thr-Asp-F-amidine (TDFA) is a highly potent, selective PAD4 (protein arginine deiminase 4) inhibitor with IC50 of 2.3 uM, displays ≥15-fold selectivity for PAD4 versus PAD1 and ≥50-fold versus PADs 2 and 3; active in cells and can be used to inhibit PAD4 activity in cellulo.
[References]
References 1. Jones JE, et al. ACS Chem Biol. 2012 Jan 20;7(1):160-5. View Related Products by Target Protein Arginine Deiminase (PAD)
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Molecular Formula ]:
C17H29FN6O7
[ Molecular Weight ]:
448.447
[ Exact Mass ]:
448.208160
[ LogP ]:
-2.92
[ Index of Refraction ]:
1.597