GS-5759

A novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM); inhibits LPS-induced TNFα production in human PBMC (IC50=0.3 nM) and in human neutrophils fMLP-induced super oxide anion production (IC50=3 nM); also is a potent inhibitor of profibrotic and proinflammatory mediator release from human lung fibroblasts.

References 1. Tannheimer SL, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):85-93. 2. Joshi T, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):324-340. View Related Products by Target Phosphodiesterase (PDE)