GWJ-A-23
Names
[ CAS No. ]:
1351930-95-4
[ Name ]:
GWJ-A-23
[Synonym ]:
Phosphonic acid, [[4-[(1-oxodecyl)amino]phenyl]methyl]-, sodium salt (1:2)
Disodium [4-(decanoylamino)benzyl]phosphonate
Biological Activity
[Description]:
GWJ-A-23 (GWJ-23, GWJ23) is a potent, selective autotaxin inhibitor with Ki of 18 nM, an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound; reduces lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-β levels, attenuates the pathogenesis of pulmonary fibrosis in vivo.
[References]
References 1. Jiang G, et al. Bioorg Med Chem Lett. 2011 Sep 1;21(17):5098-101. View Related Products by Target Autotaxin
Chemical & Physical Properties
[ Molecular Formula ]:
C17H28NO4P
[ Molecular Weight ]:
385.346
[ Exact Mass ]:
385.139496