EW-7195
Names
[ CAS No. ]:
1352609-28-9
[ Name ]:
EW-7195
Biological Activity
[Description]:
A novel potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 4.83 nM, dispalys >300-fold selectivity over p38α; decreases phosphorylated Smad2 levels and the nuclear translocation of Smad2 increased by TGF-β1, inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) and wound healing of NMuMG cells; inhibits metastasis to lung from breast tumours in xenografted mice.
[References]
References 1. Park CY, et al. Eur J Cancer. 2011 Nov;47(17):2642-53. View Related Products by Target TGF beta Receptor (TGFBR)
Chemical & Physical Properties
[ Molecular Formula ]:
C23H18N8
[ Molecular Weight ]:
406.453