AQ-101
Names
[ CAS No. ]:
1353384-61-8
[ Name ]:
AQ-101
[Synonym ]:
2-Chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenyl)acetamide
Acetamide, 2-chloro-N-(9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenyl)-
Biological Activity
[Description]:
AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53; induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo; inhibits development of ALL in nude or SCID mice with a human ALL xenograft.
[References]
References 1. Gu L, et al. Mol Cancer Ther. 2018 Feb;17(2):497-507. View Related Products by Target MDM2-p53
Chemical & Physical Properties
[ Density]:
1.7±0.1 g/cm3
[ Boiling Point ]:
639.8±55.0 °C at 760 mmHg
[ Molecular Formula ]:
C16H10ClNO5
[ Molecular Weight ]:
331.707
[ Flash Point ]:
340.7±31.5 °C
[ Exact Mass ]:
331.024750
[ LogP ]:
4.36
[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C
[ Index of Refraction ]:
1.749