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RO-2468

Names

[ CAS No. ]:
1360821-21-1

[ Name ]:
RO-2468

[Synonym ]:
(2S,3R,4S,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide
Spiro[pyrrolidine-3,3'-[3H]pyrrolo[3,2-c]pyridine]-5-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-1',2'-dihydro-2'-oxo-, (2S,3R,4S,5R)-

Biological Activity

[Description]:

A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg.

[References]

References 1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7. View Related Products by Target MDM2-p53

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
770.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H30Cl2FN5O4

[ Molecular Weight ]:
614.495

[ Flash Point ]:
419.6±32.9 °C

[ Exact Mass ]:
613.165894

[ LogP ]:
6.17

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.657

Related Compounds