GNI-50

Names

[ Name ]:
GNI-50

Biological Activity

[Description]:

GNI-50 is a potent, selective Nampt inhibitor with enzyme IC50 of 7 nM, A2780 cellular IC50 of 32 nM.GNI-50 showed excellent in vivo antitumor efficacy when dosed orally in an A2780 ovarian tumor xenograft model (TGI of 97% was observed on day 17).

[References]

1. Zheng X, et al. J Med Chem. 2013 Jun 27;56(12):4921-37.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₂N₄O₄S

[ Molecular Weight ]:
402.469

Related Compounds

wmc-50
MSN-50
Gelucire 50-02
DOWEX 50 W X 4
XM-50 Amicon
GKA 50
N~6~-(2-chlorobenzyl)-N~4~-(4-ethoxyphenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
3,4,5-trimethoxy-N-(2-oxo-2-{1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl}ethyl)benzamide
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
N1-((3-(mesitylsulfonyl)-1,3-oxazinan-2-yl)methyl)-N2-(4-methylbenzyl)oxalamide
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-{4-[ethyl(propan-2-yl)amino]phenyl}-2-(methylsulfanyl)pyridine-3-carboxamide
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide