GNI-50
Names
[ CAS No. ]:
1363154-45-3
[ Name ]:
GNI-50
Biological Activity
[Description]:
GNI-50 is a potent, selective Nampt inhibitor with enzyme IC50 of 7 nM, A2780 cellular IC50 of 32 nM.GNI-50 showed excellent in vivo antitumor efficacy when dosed orally in an A2780 ovarian tumor xenograft model (TGI of 97% was observed on day 17).
[References]
1. Zheng X, et al. J Med Chem. 2013 Jun 27;56(12):4921-37.
Chemical & Physical Properties
[ Molecular Formula ]:
C19H22N4O4S
[ Molecular Weight ]:
402.469