Bismaleimide
Names
[ CAS No. ]:
13676-54-5
[ Name ]:
Bismaleimide
[Synonym ]:
bismaleimides
mb-3000
matrimid5258
1,1'-(methylenedi-4,1-phenylene)bismaleimide
4,4'-Bismaleimidodiphenylmethane
4,4'-Methylenebis(N-phenylmaleimide)
MFCD00005507
Bis(4-maleimidophenyl)methane
N,N'-(methylenedi-p-phenylene)dimaleimide
1,1'-(Methylenebis(4,1-phenylene))bis(1H-pyrrole-2,5-dione)
MB-3000H
Diphenylmethanebismaleimide
EINECS 237-163-4
4,4'-diphenylmethanebismaleimide
xu292a
BMI
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
584.9±43.0 °C at 760 mmHg
[ Melting Point ]:
156-158 °C(lit.)
[ Molecular Formula ]:
C21H14N2O4
[ Molecular Weight ]:
358.347
[ Flash Point ]:
278.3±20.5 °C
[ Exact Mass ]:
358.095367
[ PSA ]:
74.76000
[ LogP ]:
1.95
[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C
[ Index of Refraction ]:
1.690
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ON5670000
- CHEMICAL NAME :
- Maleimide, N,N'-(methylenedi-p-phenylene)di-
- CAS REGISTRY NUMBER :
- 13676-54-5
- BEILSTEIN REFERENCE NO. :
- 0333986
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C21-H14-N2-O4
- MOLECULAR WEIGHT :
- 358.37
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 350 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 2500 ug/L
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0491-1069 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1310 No. of Facilities: 10 (estimated) No. of Industries: 2 No. of Occupations: 1 No. of Employees: 21 (estimated) No. of Female Employees: 7 (estimated)
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H315-H319-H330-H335
[ Precautionary Statements ]:
P260-P284-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic
[ Risk Phrases ]:
R23;R36/37/38
[ Safety Phrases ]:
S26-S45-S37/39
[ RIDADR ]:
UN 2811 6.1/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
ON5670000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Chem. Biol. Interact. 228 , 69-78, (2015)
6-Shogaol, a potent bioactive compound in ginger (Zingiber officinale Roscoe), has been reported for anti-inflammatory and anti-cancer activity. In this study, we investigated the effect of 6-shogaol ...
Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer.Oncotarget 6 , 35667-83, (2015)
To date, many different chemotherapeutic agents have been widely used as common treatments for oral cancers. However, their therapeutic effects have been disappointing, and these agents may have unwan...
Down-regulation of Akt by methanol extracts of Impatiens balsamina L. promotes apoptosis in human oral squamous cell carcinoma cell lines.J. Oral. Pathol. Med. 44 , 420-8, (2015)
The apoptotic activity of methanol extracts of Impatiens balsamina L. (MEIB) and related mechanisms in human oral squamous cell carcinoma (OSCC) cells have been systematically investigated.The effects...