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XD14

Names

[ CAS No. ]:
1370888-71-3

[ Name ]:
XD14

[Synonym ]:
1H-Pyrrole-2-carboxamide, 4-acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-
XD14
4-Acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide
MFCD23144071

Biological Activity

[Description]:

XD14 is a BET bromodomain inhibitor with Kd values of 160, 170, 380, 490, 830 and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2) respectively.

[In Vitro]

BET bromodomain inhibitor with Kd values of 160, 170, 380, 490, 830 and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2) respectively. XD14 also inhibits BRDT(1), CBP, p300 and BRDT(2) with Kd values of 1.2, 1.6, 2.6 and 3.7 ��M respectively.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C20H27N3O5S

[ Molecular Weight ]:
421.510

[ Exact Mass ]:
421.167145

[ LogP ]:
2.38

[ Index of Refraction ]:
1.592

[ Storage condition ]:
-20°C

Related Compounds