LY3027788

A orally active prodrug of LY3020371, which is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively; augments the antidepressant-like effects of fluoxetine or citalopram without altering plasma or brain levels of these compounds.

References 1. Witkin JM, et al. J Pharmacol Exp Ther. 2017 Apr;361(1):68-86. View Related Products by Target mGluR