Myelopeptide-2

Myelopeptide-2 is a peptide originally isolated from the supernatant of porcine bone marrow cell cultures, can restore mitogenic reactivity of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. Myelopeptide-2 also recover depressed interleukin-2 (IL-2) synthesis and interleukin-2 receptor (IL-2R) expression. Myelopeptide-2 involves in immunity homeostasis, is perspective to be applied in antitumor and antivirus research[1][2].

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

IL-2

Myelopeptide-2 (1 ng/mL-0.1 mg/mL; 72 h) restores phytohemagglutinin (PHA, 2.5 mg/mL)-induced proliferation of human peripheral blood T lymphocytes[1]. Myelopeptide-2 (0.1 mg/mL and 1 mg/mL; 1-3 d) increases the level of the reduced IL-2 synthesis in human T lymphocytes damaged by HL-60 or measles virus[1].

Myelopeptide-2 (10 μg/kg; injection; for 20-50 weeks) delays the appearance of urethane-induced tumors and decreases the number of spontaneous and urethane-induced lung tumors in mice with short-term treatment[2]. Animal Model: Male BALB/c mice (3-month-old) with spontaneous lung tumors[2] Dosage: 10 μg/kg; accompanied with 0.5 mg/kg Urethane (HY-B1207) or not Administration: Routine injection; (1) 1 injection of MP-2 and after 7 days 3 injections of MP-2 every other day, (2) or alternating with injections of urethane (4 injections of MP-2; 3 injections of urethane+4 injections of MP-2); (3) 3 injections of MP-2 every other day or (4) alternating with injections of urethane and after 3 weeks 2 injections of MP-2 monthly with one-week interval, a total of 22 injections (25 injections of MP-2; 3 injections of urethane+25 injections of MP-2). For 20-50 weeks. Result: Significantly lowered the incidence of urethane-induced lung adenomas in animals receiving 4 injections of MP-2 compared to the group receiving urethane alone or in combination with 25 injections of MP-2.

[1]. Mikhailova AA, et al. Myelopeptide-2 recovers interleukin-2 synthesis and interleukin-2 receptor expression in human T lymphocytes depressed by tumor products or measles virus. J Immunother. 2006 May-Jun;29(3):306-12.  

[2]. Mikhailova AA, et al. Effect of myelopeptide-2 on the development of spontaneous and urethane-induced tumors in mice. Bull Exp Biol Med. 2002 Jan;133(1):68-70.