AI-2
Names
[ CAS No. ]:
1380107-92-5
[ Name ]:
AI-2
Biological Activity
[Description]:
Nrf2 acticatior AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1; exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1; an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response.
[References]
References 1. Hur W, et al. Chem Biol. 2010 May 28;17(5):537-47. View Related Products by Target Keap1-Nrf2
Chemical & Physical Properties
[ Molecular Formula ]:
C18H15ClN2O3
[ Molecular Weight ]:
342.779