2-Acetoxyacetyl chloride

Names

[ Name ]:
2-Acetoxyacetyl chloride

[Synonym ]:
MFCD00011535
(2-chloro-2-oxoethyl) acetate
2-Chloro-2-oxoethyl acetate
EINECS 237-542-4
2-Acetoxyacetyl chloride
Acetyl chloride, 2-(acetyloxy)-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
163.7±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₅ClO₃

[ Molecular Weight ]:
136.534

[ Flash Point ]:
71.1±0.0 °C

[ Exact Mass ]:
135.992722

[ PSA ]:
43.37000

[ LogP ]:
0.56

[ Vapour Pressure ]:
2.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.425

[ Storage condition ]:
water-free area

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H335

[ Supplemental HS ]:
Reacts violently with water.

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R14;R34

[ Safety Phrases ]:
S23-S26-S27-S36/37/39-S45-S8

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2915390090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915390090

[ Summary ]:
2915390090. esters of acetic acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%

Articles

Entrapment and kinetic resolution of stabilized axial and equatorial conformers of spiro-β-lactams.

J. Org. Chem. 76(15) , 5999-6006, (2011)

The facile synthesis of the stabilized axial and equatorial conformers of spiro-β-lactams was achieved via entrapment of cyclohexanone imines (Schiff bases) with acetoxyacetyl chloride in a [2 + 2]-cy...

N-glycolylhydroxamic acids: an improved synthetic method and the in situ generation and intramolecular rearrangement of N-acetoxy-N-glycolyl-2-aminofluorene.

Chem. Res. Toxicol. 1(4) , 222-7, (1988)

A new and improved method for the synthesis of glycolylhydroxamic acids is described. The two-step method involves acylation of arylhydroxylamines with acetoxyacetyl chloride, followed by saponificati...