coenzyme B12

Names

[ Name ]:
coenzyme B12

[Synonym ]:
5'-Deoxyadenosylcobalamin
a-(5,6-Dimethylbenzimidazolyl)-Co-5'-deoxyadenosylcobamide
DBC
5,6-Dimethylbenzimidazolyl-Co-5'-deoxyadenosylcobamide
Coenzyme B12
Dibenzcozamide
Coenzyme B12
DBC coenzyme
Adenosyl cobalamine
Indusil T
α-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
Vitamin B12 coenzyme
5,6-Dimethylbenzimidazolylcobamide 5'-Deoxyadenosine
Dimebenzcozamide
Adenosyl-B12
Calomide
AdoCbl
DBC (VAN)
Cobamamide
Cobalamine coenzyme
Deoxyadenosylcobalamin
5'-Deoxyadenosylcobalamine
Cobalamin coenzyme
a-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
Co-(5'-Deoxy-5'-adenosyl)-a-(5,6-dimethyl-1H-benzimidazolyl)cobamide
5'-Deoxyadenosyl Vtamin B12
Funacomide
Dibencozide
Desoxyadenosylcobalamine

Biological Activity

[Description]:

Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B12 which is a cofactor for methylmalonyl CoA mutase[1]

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Adenosylcobalamin serves as the cofactor for a group of enzymes that catalyze unusual rearrangement or elimination reactions[1].

[References]

[1]. Kumudha A, et al. Characterization of vitamin B12 in Dunaliella salina. J Food Sci Technol. 2016 Jan;53(1):888-94.

[2]. Marsh EN, et al. Adenosylcobalamin enzymes: Theory and experiment begin to converge. Biochim Biophys Acta. 2012 Nov;1824(11):1154-64.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₂H₉₉CoN₁₈O₁₇P

[ Molecular Weight ]:
1579.582

[ Exact Mass ]:
1578.658325

[ PSA ]:
583.18000

[ LogP ]:
6.19200

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GG3800000

CHEMICAL NAME :: Cobinamide, O-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole

CAS REGISTRY NUMBER :: 13870-90-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C72-H100-Co-N18-O17-P

MOLECULAR WEIGHT :: 1579.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GG3800000

[ HS Code ]:
2936260000

Customs

[ HS Code ]: 2936260000

Articles

Thermophilic Coenzyme B12-Dependent Acyl Coenzyme A (CoA) Mutase from Kyrpidia tusciae DSM 2912 Preferentially Catalyzes Isomerization of (R)-3-Hydroxybutyryl-CoA and 2-Hydroxyisobutyryl-CoA.

Appl. Environ. Microbiol. 81 , 4564-72, (2015)

The recent discovery of a coenzyme B12-dependent acyl-coenzyme A (acyl-CoA) mutase isomerizing 3-hydroxybutyryl- and 2-hydroxyisobutyryl-CoA in the mesophilic bacterium Aquincola tertiaricarbonis L108...

Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.

J. Biomol. Screen. 15 , 314-20, (2010)

Protein stabilization upon ligand binding has frequently been used to identify ligands for soluble proteins. Methods such as differential scanning fluorimetry (DSF) and differential static light scatt...

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

Proc. Natl. Acad. Sci. U. S. A. 103 , 15835-40, (2006)

The 3D structures of human therapeutic targets are enabling for drug discovery. However, their purification and crystallization remain rate determining. In individual cases, ligands have been used to ...