1-Acetylpiperazine

Names

[ Name ]:
1-Acetylpiperazine

[Synonym ]:
MFCD00058676
EINECS 237-659-0
1-(Piperazin-1-yl)ethanon
T6M DNTJ DV1
1-(Piperazin-1-yl)ethanone
Ethanone, 1-(1-piperazinyl)-
1-(1-Piperazinyl)ethanone
1-piperazin-1-ylethanone

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
257.9±33.0 °C at 760 mmHg

[ Melting Point ]:
31-34 °C(lit.)

[ Molecular Formula ]:
C₆H₁₂N₂O

[ Molecular Weight ]:
128.172

[ Flash Point ]:
109.8±25.4 °C

[ Exact Mass ]:
128.094955

[ PSA ]:
32.34000

[ LogP ]:
-0.77

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.466

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.

Bioorg. Med. Chem. Lett. 21 , 5881-5887, (2011)

A group of 2-substituted N-(naphth-1-ylmethyl)pyrimidin-4-amines (6a-k) and N-benzhydrylpyrimidin-4-amines (7a-k) in conjunction with varying steric and electronic properties at the C-2 position were ...

Synthesis and acetylcholinesterase and butyrylcholinesterase inhibitory activities of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives.

Arch. Pharm. (Weinheim) 345(3) , 175-84, (2012)

A series of novel 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives were synthesized. The cholinesterase inhibition assays indicated that most synthesized compounds exhibited good activ...

A joint theoretical and experimental study of 1-acetylpiperazine: conformational stability, infrared and Raman spectra.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 127 , 388-95, (2014)

Infrared and Raman spectra of 1-acetylpiperazine (1-ap) have been recorded in the region of 4000-40cm(-1). The conformational isomers, optimized geometric parameters, normal mode frequencies and corre...