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3-O-Decyclopropyl Roflumilast

Names

[ CAS No. ]:
1391052-76-8

[ Name ]:
3-O-Decyclopropyl Roflumilast

[Synonym ]:
Benzamide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxy-
N-(3,5-Dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide
N-(3,5-dichloropyridin-4-yl)-4-(difluoroMethoxy)-3-hydroxybenzaMide
3-(hydroxy)-N-(3,5-dichloro-4-pyridinyl) -4-difluoromethoxy) benzamide
Roflumilast Impurity E
Roflumilast Impurity 2

Biological Activity

[Description]:

Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast(Daliresp) is a drug which acts as a selective and long-acting inhibitor of the enzyme PDE-4 with an IC50 value of 0.8 nM.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Inflammation/Immunology

[Related Small Molecules]

3-Isobutyl-1-methylxanthine | rolipram | PF-04957325 | AN-2728 | GLPG1690 | BAY-60-7550 | Icariin | Ibudilast | PF-8380 | TAK-063 | Dipyridamole | Cilostazol | GSK256066 | Cialis | Pentoxifylline

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
397.4±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H8Cl2F2N2O3

[ Molecular Weight ]:
349.117

[ Flash Point ]:
194.2±27.9 °C

[ Exact Mass ]:
347.988007

[ PSA ]:
71.45000

[ LogP ]:
3.37

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.626

[ Storage condition ]:
2-8℃

Related Compounds