ADAMTS-5 inhibitor 15f
Names
[ CAS No. ]:
1394122-49-6
[ Name ]:
ADAMTS-5 inhibitor 15f
Biological Activity
[Description]:
ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation.
[References]
References 1. Deng H, et al. J Med Chem. 2012 Aug 23;55(16):7061-79. View Related Products by Target Matrix Metalloproteinase (MMP)
Chemical & Physical Properties
[ Molecular Formula ]:
C26H39N9O2S
[ Molecular Weight ]:
541.719