16α-Hydroxyprednisolone

Names

[ Name ]:
16α-Hydroxyprednisolone

[Synonym ]:
MFCD00872019
(11β,16α)-11,16,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)-
EINECS 237-731-1
11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione
Budesonide Impurity 1

Biological Activity

[Description]:

16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Xavier Matabosch, et al. Identification of budesonide metabolites in human urine after oral administration. Anal Bioanal Chem. 2012 Aug;404(2):325-40.

[2]. G Jönsson, et al. Budesonide is metabolized by cytochrome P450 3A (CYP3A) enzymes in human liver. Drug Metab Dispos. 1995 Jan;23(1):137-42.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
591.5±50.0 °C at 760 mmHg

[ Melting Point ]:
235-238ºC

[ Molecular Formula ]:
C₂₁H₂₈O₆

[ Molecular Weight ]:
376.443

[ Flash Point ]:
325.6±26.6 °C

[ Exact Mass ]:
376.188599

[ PSA ]:
115.06000

[ LogP ]:
0.95

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.630

[ Storage condition ]:
-20°C Freezer

MSDS

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Safety Information

[ HS Code ]:
2937210000

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%