Neomycin

Names

[ Name ]:
Neomycin

[Synonym ]:
Actilin
neomin
Neosulf
neomcin
nivemycin
Myacine
EINECS 215-773-1
NEOMIX
Endomixin
Bykomycin
Neobiosamine B
Framygen
Jernadex
Antibiotique EF 185
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-b-L-idopyranosyl)-b-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-a-D-glucopyranoside
myacyne
Enterfram
α-D-Glucopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-2-[[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-
Bycomycin
neolate
Neomyacin
Neobrettin
Framycetin
Biosol
Tuttomycin
a-D-glucopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-2-[[3-O-(2,6-diamino-2,6-dideoxy-b-L-idopyranosyl)-b-D-ribofuranosyl]oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-
Fraquinol
Neomycin
(1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside
neomas

Biological Activity

[Description]:

Neomycin is an aminoglycoside antibiotic. Neomycin can be used for the research of external or internal bacterial infections, is primarily administered in veterinary medicine as a sulfate salt[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Liu Y, et al. Pharmacokinetics of neomycin sulfate after intravenous and oral administrations in swine. J Vet Pharmacol Ther. 2021 Sep;44(5):850-853.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
927.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₅₂N₆O₂₅S₃

[ Molecular Weight ]:
614.644

[ Flash Point ]:
514.5±34.3 °C

[ Exact Mass ]:
614.312256

[ PSA ]:
602.05000

[ LogP ]:
-3.65

[ Appearance of Characters ]:
powder

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.675

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QP3850000

CHEMICAL NAME :: Neomycin

CAS REGISTRY NUMBER :: 1404-04-2

LAST UPDATED :: 199609

WISWESSER LINE NOTATION :: T6OTJ CZ DQ EQ F1Z BO- CT5OTJ B1Q DQ EO- CL6TJ AZ BQ EZ DO- BT6OTJ CZ DQ EQ F1Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 220 mg/kg/2D

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human

DOSE/DURATION :: 57 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - changes in cochlear structure or function Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 633 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2880 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 116 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg/5D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

REFERENCE :: CHRTBC Chromosomes Today. (George Allen & Unwin Ltd., 40 Museum St., London WC1A 1LU, UK) V.1- 1966- Volume(issue)/page/year: 4,277,1973 *** REVIEWS *** TOXICOLOGY REVIEW CPJOAC Canadian Pharmaceutical Journal. (Canadian Pharmaceutical Assoc., 101-1815 Alta Vista Dr., Ottawa, Ont., Canada) V.1- 1868- Volume(issue)/page/year: 108(3),88,1975 TOXICOLOGY REVIEW CLANA4 Clinical Anesthesia. (Philadelphia, PA 19103) V.1-11, 1963-76. Volume(issue)/page/year: 10(Pt 1),283,1973 TOXICOLOGY REVIEW MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.) V.33-115, 1886-1973. Volume(issue)/page/year: 115,1661,1973 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3705 No. of Facilities: 567 (estimated) No. of Industries: 2 No. of Occupations: 11 No. of Employees: 19997 (estimated) No. of Female Employees: 16532 (estimated)

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R42/43

[ Safety Phrases ]:
S22;S45;S36/S37

[ WGK Germany ]:
3

[ RTECS ]:
QP4375000