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Vazegepant hydrochloride

Names

[ CAS No. ]:
1414976-20-7

[ Name ]:
Vazegepant hydrochloride

Biological Activity

[Description]:

Vazegepant (BHV-3500) hydrochloride is a highly affinity CGRP receptor antagonist (hCGRP Ki= 0.023 nM). Vazegepant hydrochloride is the first intranasal gepant for migraine. Vazegepant hydrochloride may be helpful in effective management of COVID-19 associated pulmonary inflammation[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CGRP Receptor
Signaling Pathways >> Neuronal Signaling >> CGRP Receptor
Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[Target]

Ki: 0.023 nM (hCGRP)[3]


[References]

[1]. Moreno-Ajona D, et al. Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment?. Curr Opin Neurol. 2020;33(3):309-315.

[2]. Mehta PP, et al. Novel and Evolving Therapies for COVID-19 Related Pulmonary Complications. Am J Med Sci. 2021;361(5):557-566.

[3]. Moreno-Ajona D, Pérez-Rodríguez A, Goadsby PJ. Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment?. Curr Opin Neurol. 2020;33(3):309-315.

Chemical & Physical Properties

[ Molecular Formula ]:
C36H47ClN8O3

[ Molecular Weight ]:
675.26

Related Compounds