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HJC-0338

Names

[ CAS No. ]:
1417718-39-8

[ Name ]:
HJC-0338

[Synonym ]:
Benzenamine, N-(2,5-dichlorophenyl)-2,4,6-trimethyl-
N-(2,5-Dichlorophenyl)-2,4,6-trimethylaniline

Biological Activity

[Description]:

HJC-0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2; exhibits no inhibition of EPAC1-mediated Rap1-GDP exchange activity at 25 uM; selectively block cAMP-induced EPAC2 activation but do not inhibit cAMP-mediated PKA activation.

[References]

References 1. Chen H, et al. J Med Chem. 2013 Feb 14;56(3):952-62. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
355.9±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H15Cl2N

[ Molecular Weight ]:
280.192

[ Flash Point ]:
169.0±27.9 °C

[ Exact Mass ]:
279.058167

[ LogP ]:
6.07

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.617

Related Compounds