Piperazine Hexahydrate

Names

[ CAS No. ]:
142-63-2

[ Name ]:
Piperazine Hexahydrate

[Synonym ]:
Diethylenediamine Hexahydrate
piperazine,hexahydrate
Piperazine hydrate
Piperazine hexahydrate
EINECS 203-808-3
MFCD00149389

Chemical & Physical Properties

[ Density]:
1.92g/cm3

[ Boiling Point ]:
145-156 °C(lit.)

[ Melting Point ]:
42-44 °C(lit.)

[ Molecular Formula ]:
C₄H₂₂N₂O₆

[ Molecular Weight ]:
194.22700

[ Flash Point ]:
190 °F

[ Exact Mass ]:
194.14800

[ PSA ]:
79.44000

[ Vapour Pressure ]:
4.05mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM0850000

CHEMICAL NAME :: Piperazine, hexahydrate

CAS REGISTRY NUMBER :: 142-63-2

LAST UPDATED :: 199504

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H10-N2.6H2-O

MOLECULAR WEIGHT :: 194.28

WISWESSER LINE NOTATION :: T6N DNTJ &QH 6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,336,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84706 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84706 No. of Facilities: 9 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 127 (estimated) No. of Female Employees: 45 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H317-H334-H361fd

[ Precautionary Statements ]:
P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34;R42/43;R52/53

[ Safety Phrases ]:
S22-S26-S36/37/39-S45-S61

[ RIDADR ]:
UN 2579 8/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
TM0850000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2933599090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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