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Lulizumab Pegol

Names

[ CAS No. ]:
1421830-13-8

[ Name ]:
Lulizumab Pegol

Biological Activity

[Description]:

Lulizumab pegol (BMS-931699) is an anti-CD28 antibody antagonist. Lulizumab pegol effectively inhibits T-cell proliferation and it can be used for the reseach of kidney transplantation and autoimmunity disease[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vitro]

BMS-931699 通过生物大分子相互作用分析系统显示出对 T 细胞增殖的 Kd 为 0.41 nM[1]。 BMS-931699 通过混合淋巴细胞反应 (MLR) 诱导的 T 细胞增殖的 EC50 为 2.9 nM 以及对全血中 CD28 受体占用 (RO) 的 EC50 为 4.4 nM[1]。

[References]

[1]. Yang Z, et al. Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699. J Pharmacol Exp Ther. 2015 Dec;355(3):506-15.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds