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AC 186

Names

[ CAS No. ]:
1421854-16-1

[ Name ]:
AC 186

[Synonym ]:
4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Phenol, 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]-
AC-186

Biological Activity

[Description]:

AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender specific neuroprotection in a Parkinson’s Disease rat model[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR
Research Areas >> Neurological Disease

[Target]

ERβ:6 nM (EC50)

ERα:5000 nM (EC50)


[References]

[1]. McFarland K, et al. AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem Neurosci. 2013 Sep 18;4(9):1249-55.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
396.9±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H17F3O

[ Molecular Weight ]:
306.322

[ Flash Point ]:
172.4±22.4 °C

[ Exact Mass ]:
306.123138

[ LogP ]:
4.24

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.566

Related Compounds