Antimalarial compound 49c

Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM; blocks invasion and egress of P. falciparum without impacting intraerythrocytic growth, specifically inhibits recombinant PfPMIX and PfPMX (r-PMIXFlag and r-PMXFlag), recapitulating the defect in invasion and egress of P. falciparum in the erythrocytic blood stages; also interferes with invasion and egress in T. gondii by targeting TgASP3

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