T-3775440
Names
[ CAS No. ]:
1422620-34-5
[ Name ]:
T-3775440
Biological Activity
[Description]:
T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM; displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B); disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models.
[References]
References 1. Takagi S, et al. Cancer Res. 2017 Jun 30. pii: canres.3502.2016. 2. Ishikawa Y, et al. Mol Cancer Ther. 2017 Feb;16(2):273-284. View Related Products by Target Histone Demethylase
Chemical & Physical Properties
[ Molecular Formula ]:
C18H22N4O
[ Molecular Weight ]:
310.401