Amthamine dihydrobromide

Names

[ Name ]:
Amthamine dihydrobromide

[Synonym ]:
cc-388
Amthamine dihydrobromide
Hispidulin
2-amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide
2-Amino-4-methyl-5-thiazoleethanamine dihydrobromide

Biological Activity

[Description]:

Amthamine is a histamine receptor (H1R-H4R) agonist. Amthamine can produce liver congestion and necrosis of liver cells. Amthamine can be used to study the induction effect of H1R-H4 agonist on hepatotoxicity [1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Trivendra Tripathi, et al. Hepatotoxicity Due to Histamine Trifluoro-Methyl Toluidide, Amthamine, R-(-)-α-Methyl Histamine and Clobenpropit (H1R-H4R-Agonists, Respectively) in Rabbit Experimental Model. American Medical Journal. 2010, 1 (1): 1-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₃Br₂N₃S

[ Molecular Weight ]:
319.06

[ Exact Mass ]:
316.92000

[ PSA ]:
93.90000

[ LogP ]:
3.08150

MSDS

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Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists.

Pharmacol. Rep. 62(5) , 917-25, (2010)

The present study was designed to delineate the immunomodulatory role of histamine receptors (H1R and H2R) and their antibody generation in a rabbit model. Six groups containing 18 rabbits each receiv...

Analysis of the histamine H2-receptor in human monocytes.

Biochem. Pharmacol. 92(2) , 369-79, (2014)

Histamine receptors are G-protein-coupled receptors (GPCRs). Canonically, the histamine H2-receptor (H2R) couples to Gs-proteins and activates adenylyl cyclases (ACs) with subsequent adenosine-3',5'-c...

Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis.

Clin. Sci. 127(7) , 435-48, (2014)

Histamine H2 receptor (H2R) blockade has been reported to be beneficial for patients with chronic heart failure (CHF), but the mechanisms involved are not entirely clear. In the present study, we asse...