dihydrostreptomycin sesquisulfate salt

Names

[ Name ]:
dihydrostreptomycin sesquisulfate salt

[Synonym ]:
didromycin
dihydrostreptomycin3/2sulfate
Guanidine, N'',N'''''-[(1S,2S,3R,4S,5S,6R)-4-[[5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl]oxy]-2,5,6-trihydroxy-1,3-cyclohexanediyl]bis-, su lfate (2:3) (salt)
didromycine
panstreptin
dihydrostreptomycin sesquisulfate
Sol-Mycin
Prestwick_173
dihydrostreptomycin,sulfate
Double-Mycin
2,2'-[(1S,2S,3R,4S,5S,6R)-4-({5-Deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl}oxy)-2,5,6-trihydroxy-1,3-cyclohexanediyl]diguanidine sulfate (2:3)
dihydrostreptomycin solution
Dihydrostreptomycin,Sufat
StreptoMagna

Chemical & Physical Properties

[ Boiling Point ]:
954.5ºC at 760 mmHg

[ Molecular Formula ]:
C₄₂H₈₈N₁₄O₃₆S₃

[ Molecular Weight ]:
1461.415

[ Flash Point ]:
531.1ºC

[ Exact Mass ]:
1460.464722

[ PSA ]:
918.12000

[ Appearance of Characters ]:
crystalline

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 50 mg/mL, clear, faintly yellow

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK4950000

CHEMICAL NAME :: Streptomycin, dihydro-, sulfate

CAS REGISTRY NUMBER :: 1425-61-2

LAST UPDATED :: 199112

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H41-N7-O12.xH2-O4-S

MOLECULAR WEIGHT :: 1270.25

WISWESSER LINE NOTATION :: T6OTJ CM1 DQ EQ F1Q BO- CT5OTJ DQ D1Q E1 BO- AL6TJ BQ CQ DMYZUM EQ FMYZUM &WSQQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,597,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >600 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 1,49,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,285,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 761 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 18,444,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 137 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 18,444,1973 *** REVIEWS *** TOXICOLOGY REVIEW PMMDAE Panminerva Medica. (Edizioni Minerva Medica, Casella Postale 491, Turin, Italy) V.1- 1959- Volume(issue)/page/year: 16,9,1974

Safety Information

[ WGK Germany ]:
3

[ RTECS ]:
WK2236000