HBX 28258

Names

[ Name ]:
HBX 28258

Biological Activity

[Description]:

HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrestes HCT116 cancer cells in G1 phase.

[References]

References 1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77. View Related Products by Target Deubiquitinase (DUB)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₀ClN₃O

[ Molecular Weight ]:
435.996

Related Compounds

HBX
HBX 19818
HBX 41108
aluminum,2-methyl-1,3,5-trinitrobenzene,1,3,5-trinitro-1,3,5-triazinane
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
(R)-1-Cyclobutyl-2,2,2-trifluoroethanamine
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
7-[1,1'-Biphenyl]-3-yl-3-hydroxy-2-naphthalenecarboxylic acid
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
5,5-dimethyl-2,3,4,5-tetrahydro-1H-1-benzazepine
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde