RORγt-IN-9a

Names

[ Name ]:
RORγt-IN-9a

Biological Activity

[Description]:

A potent, selective, CNS penetrant, orally bioavailable RORγt with pIC50 of 8.3 in FRET assays; has TH17 pEC50 of 7.3, demonstrates excellent in vivo efficacy in EAE mice.

[References]

References 1. Wang Y, et al. ACS Med Chem Lett. 2015 May 26;6(7):787-92. View Related Products by Target ROR

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₆Cl₂F₃NO₄S

[ Molecular Weight ]:
518.328

Related Compounds

RORγt/DHODH-IN-2
RORγt Inverse agonist 10
RORγt inverse agonist 23
RORγt modulator 2
RORγt inverse agonist 30
RORγt modulator 3
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
2-(Difluoromethyl)-1,2-dimethylcyclopentan-1-ol
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
Ethyl[(1-ethyl-1H-pyrazol-5-yl)imino]methyl-lambda6-sulfanone
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
4-Amino-1-(4-methylpyrimidin-5-yl)cyclohexane-1-carboxylic acid