NBD-11021
Names
[ CAS No. ]:
1427304-84-4
[ Name ]:
NBD-11021
Biological Activity
[Description]:
A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction; inhibits the CD4-dependent virus in a dose-dependent manner with IC50 of 2.4 uM; also weakly shows HIV-1 RT inhibition with IC50 of 43.4 uM; exhibits pan-neutralization activity against a panel of 56 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates (IC50 as low as 270 nM). HIV Preclinical
[References]
References 1. Curreli F, et al. J Med Chem. 2015 Sep 10;58(17):6909-6927. View Related Products by Target HIV HIV
Chemical & Physical Properties
[ Molecular Formula ]:
C22H25ClN4O2S
[ Molecular Weight ]:
444.978