HXJ 42
Names
[ CAS No. ]:
1428640-39-4
[ Name ]:
HXJ 42
Biological Activity
[Description]:
A PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells; effectively rescues Zap70(AS) OT-I cells from negative selection.
[References]
References 1. Au-Yeung BB, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88. 2. Au-Yeung BB, et al. Nat Immunol. 2014 Jul;15(7):687-94. View Related Products by Target T Cell Receptor (TCR)
Chemical & Physical Properties
[ Molecular Formula ]:
C15H15Cl2N5O
[ Molecular Weight ]:
352.219