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N1-Methylpseudouridine-5′-triphosphate

Names

[ CAS No. ]:
1428903-59-6

[ Name ]:
N1-Methylpseudouridine-5′-triphosphate

Biological Activity

[Description]:

N1-Methylpseudouridine-5′-triphosphate (N1-Me-Pseudo UTP) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Andries O, Mc Cafferty S, De Smedt SC, Weiss R, Sanders NN, Kitada T. N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. J Control Release. 2015;217:337-344.

Chemical & Physical Properties

[ Density]:
2.010±0.06 g/cm3

[ Molecular Formula ]:
C10H17N2O15P3

[ Molecular Weight ]:
498.17

[ Storage condition ]:
-20°C

Related Compounds