MPK-09

Names

[ Name ]:
MPK-09

Biological Activity

[Description]:

A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator; exhibits potent cytotoxic activity against BT474 (p53 E285K) cell line (IC50=0.6 uM) as compared to wt p53 A549 (IC50=2.8 uM) and HeLa (IC50 = 4 uM) cells; enhances PARP cleavage, activates caspase 3 expressions and induces apoptosis.

[References]

References 1. Metri PK, et al. ACS Chem Biol. 2013 Jul 19;8(7):1429-34. View Related Products by Target MDM2-p53

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₄O₆

[ Molecular Weight ]:
418.53

Related Compounds

AG-09/1
DGY-09-192
RS 09
CY 09
(E)-4-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methylpentanoyl]amino]-1-oxopentan-2-yl]amino]-4-oxobut-2-enoic acid
ESI 09
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
3-(2-Bromo-4-methylphenyl)-1,1,1-trifluoropropan-2-ol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide