ND-654(ND654

ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively; inhibits HepG2 cell fatty acid synthesis with an EC50 of 14 nM, and reduces both rat hepatic malonyl-CoA and rat hepatic fatty acid synthesis with ED50 values of 0.34 mg/kg and 0.30 mg/kg at Cmax, respectively; mimics the effects of ACC phosphorylation inhibits hepatic DNL and the development of HCC, selectively targets the liver and inhibits HCC proliferation, improves survival of tumor-bearing rats when used alone and in combination with the multi-kinase inhibitor sorafenib.

References 1. Lally JSV, et al. Cell Metab. 2019 Jan 8;29(1):174-182.e5. View Related Products by Target Acetyl-CoA Carboxylase (ACC)