(Acetylmethylene)triphenylphosphorane
Names
[ CAS No. ]:
1439-36-7
[ Name ]:
(Acetylmethylene)triphenylphosphorane
[Synonym ]:
2-Propanone, 1-(triphenylphosphoranylidene)-
EINECS 215-878-2
1-(Triphenylphosphoranylidene)-2-propanone
1-Triphenylphosphoranylidene-2-propanone
1-(triphenyl-λ<sup>5</sup>-phosphanylidene)propan-2-one
(Acetylmethylene)triphenylphosphorane
(Triphenylphosphoranylidene)-2-propanone
1-(Triphenylphosphoranylidene)propan-2-one
2-Propanone, 1- (triphenylphosphoranylidene)-
1-(Triphenylphosphoranylidene)acetone
MFCD00008774
1-Triphenylphosphanylidene-propan-2-one
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
478.5±28.0 °C at 760 mmHg
[ Melting Point ]:
203-205 °C(lit.)
[ Molecular Formula ]:
C21H19OP
[ Molecular Weight ]:
318.349
[ Flash Point ]:
243.2±24.0 °C
[ Exact Mass ]:
318.117340
[ PSA ]:
26.88000
[ LogP ]:
3.22
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.611
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UC3900000
- CHEMICAL NAME :
- 2-Propanone, triphenylphosphoranylidene-
- CAS REGISTRY NUMBER :
- 1439-36-7
- BEILSTEIN REFERENCE NO. :
- 0750077
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C21-H19-O-P
- MOLECULAR WEIGHT :
- 318.37
- WISWESSER LINE NOTATION :
- 1V1UPR&R&R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01327 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 520 mg/kg/30D-I
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach Blood - normocytic anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 9,2641,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1560 mg/kg/26W-I
- TOXIC EFFECTS :
- Blood - changes in cell count (unspecified) Blood - changes in spleen Biochemical - Metabolism (Intermediary) - other proteins
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 9,2641,1975
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Risk Phrases ]:
R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin .
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
UC3900000
Articles
J. Org. Chem. 72 , 2427, (2007)
Mechanistic studies on the intramolecular nucleophilic substitution with allylic rearrangement (SNi' reaction) and a new stereoselective access to substituted cyclobutanones are reported. 4,4-Dialkyl-...
Synthesis , 1359, (2007)