Divin

Names

[ Name ]:
Divin

[Synonym ]:
N'-[(E)-(2-Hydroxy-1-naphthyl)methylene]-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide
MFCD03664181
1H-Benzimidazole-1-propanoic acid, 2-methyl-, 2-[(1E)-(2-hydroxy-1-naphthalenyl)methylene]hydrazide

Biological Activity

[Description]:

A potent chelator of iron that arrests late stages of cytokinesis by blocking the physical process of constriction in dividing cells; also is a small molecule inhibitor of bacterial divisome assembly; downregulates the transcription of genes encoding proteins involved in cell division, reduce protein biosynthesis, and affects the spatiotemporal localization of the division machinery.

[References]

References 1. Santos TMA, et al. ACS Chem Biol. 2017 Dec 11. doi: 10.1021/acschembio.7b00560. 2. Eun YJ, et al. J Am Chem Soc. 2013 Jul 3;135(26):9768-76. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₂H₂₀N₄O₂

[ Molecular Weight ]:
372.420

[ Exact Mass ]:
372.158630

[ LogP ]:
5.37

[ Index of Refraction ]:
1.667

Safety Information

[ RIDADR ]:
NONH for all modes of transport