ROMK-IN-25
Names
[ CAS No. ]:
1443735-02-1
[ Name ]:
ROMK-IN-25
Biological Activity
[Description]:
ROMK-IN-25 is a potent and selective ROMK channel (KCNJ1) inhibitor with IC50 of 72 nM; displays improved ROMK/hERG selectivity (866-fold over hERG), and improved pharmacokinetic profiles; does not evoke QTc prolongation in an in vivo cardiovascular dog model.
[References]
References 1. Zhu Y, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5695-5702. View Related Products by Target Potassium Channel
Chemical & Physical Properties
[ Molecular Formula ]:
C23H23FN8O2
[ Molecular Weight ]:
462.489