4'-Chlorodiazepam

Names

[ Name ]:
4'-Chlorodiazepam

[Synonym ]:
Chlorodiazepam
4'-Chlorodiazepam
7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
Ro-5-4864
7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one

Chemical & Physical Properties

[ Density]:
1.35g/cm3

[ Boiling Point ]:
517.1ºC at 760mmHg

[ Melting Point ]:
160-163ºC

[ Molecular Formula ]:
C₁₆H₁₂Cl₂N₂O

[ Molecular Weight ]:
319.18500

[ Flash Point ]:
266.6ºC

[ Exact Mass ]:
318.03300

[ PSA ]:
32.67000

[ LogP ]:
3.30780

[ Vapour Pressure ]:
8.43E-11mmHg at 25°C

[ Index of Refraction ]:
1.647

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF0500000

CHEMICAL NAME :: 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-

CAS REGISTRY NUMBER :: 14439-61-3

BEILSTEIN REFERENCE NO. :: 0685202

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-Cl2-N2-O

MOLECULAR WEIGHT :: 319.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 10 nmol/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 49,115,1990

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22

[ RIDADR ]:
UN 2811

[ RTECS ]:
DF0500000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues.

J. Med. Chem. 49 , 5845-8, (2006)

Cultured rat astrocytes and C6 rat glioma were used as a differential screen for a variety of 1,2,3,4-tetrahydroisoquinoline (THI) derivatives. Compound 1 [1-(biphenyl-4-ylmethyl)-1,2,3,4-tetrahydrois...

Investigation into mechanisms mediating the inhibitory effect of 1,4-benzodiazepines on mast cells by gene expression profiling.

Life Sci. 92(6-7) , 345-51, (2013)

This study aims to identify by a molecular genetic approach potential targets in mast cells at which 1,4-benzodiazepines may cause their inhibitory effect on mast cell activity.Gene expression analyse...

Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis.

Biochem. Pharmacol. 97 , 99-110, (2015)

As a major regulator in obesity and its associated metabolic complications, the proper functioning of adipocytes is crucial for health maintenance, thus serving as an important target for the developm...