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(2S,3S)-3-[N-(Quinoxaline-2-carbonyl)-L-asparaginyl]amino-2-hydroxy-4- phenylbutanoyl-L-proline, tert-butylamide

Names

[ CAS No. ]:
144779-91-9

[ Name ]:
(2S,3S)-3-[N-(Quinoxaline-2-carbonyl)-L-asparaginyl]amino-2-hydroxy-4- phenylbutanoyl-L-proline, tert-butylamide

[Synonym ]:
AHPBA analog

Biological Activity

[Description]:

R-87366 is a water-soluble human immunodeficiency virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a Ki value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV)[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease

[Target]

Ki: 11 nM (HIV protease)[1]. IC90: 0.5 μM (HIV-1IIIB acutely infected cells)[1]


[In Vitro]

R-87366 对人类免疫缺陷病毒蛋白酶具有强效抑制作用，Ki 值为 11 nM[1]。 R-87366 对 HIV-1IIIB 急性感染细胞具有活性，IC90 值为 0.5 μM[1]。 R-87366 具有中等水溶性[1]。 R-87366 (0.25 μM; 0.5 μM) 对慢性感染的 Molt-4/HIV-1IIIB 细胞也有活性，并抑制 p55 蛋白水解加工成 p17[1]。

[References]

[1]. T Komai, et al. In vitro and ex vivo anti-human immunodeficiency virus (HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid. Biol Pharm Bull. 1997 Feb;20(2):175-80.  

Chemical & Physical Properties

[ Density]:
1.311g/cm3

[ Boiling Point ]:
1055.5ºC at 760 mmHg

[ Molecular Formula ]:
C32H39N7O6

[ Molecular Weight ]:
617.69500

[ Flash Point ]:
592.1ºC

[ Exact Mass ]:
617.29600

[ PSA ]:
208.17000

[ LogP ]:
3.94070

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.622

Related Compounds