<Suppliers Price>

Chlojaponilactone B

Names

[ CAS No. ]:
1449382-91-5

[ Name ]:
Chlojaponilactone B

[Synonym ]:
Cycloprop[2,3]indeno[5,6-b]furan-2(4H)-one, 4-(acetyloxy)-4a,5,5a,6,6a,6b-hexahydro-3,6b-dimethyl-5-methylene-, (4R,4aS,5aS,6aR,6bS)-
(4R,4aS,5aS,6aR,6bS)-3,6b-Dimethyl-5-methylene-2-oxo-2,4,4a,5,5a,6,6a,6b-octahydrocyclopropa[2,3]indeno[5,6-b]furan-4-yl acetate

Biological Activity

[Description]:

Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Inflammation/Immunology

[References]

[1]. Shaoxia Ye, et al. Chlojaponilactone B Attenuates Lipopolysaccharide-Induced Inflammatory Responses by Suppressing TLR4-Mediated ROS Generation and NF-κB Signaling Pathway. Molecules. 2019 Oct 16;24(20):3731.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
458.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H18O4

[ Molecular Weight ]:
286.322

[ Flash Point ]:
236.2±27.1 °C

[ Exact Mass ]:
286.120514

[ LogP ]:
2.76

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.583

[ Storage condition ]:
2-8℃

Related Compounds