MRS 2179 tetrasodium
Names
[ CAS No. ]:
1454889-37-2
[ Name ]:
MRS 2179 tetrasodium
[Synonym ]:
Tetrasodium 9-(2-deoxy-3,5-di-O-phosphonato-α-D-erythro-pentofuranosyl)-N-methyl-9H-purin-6-amine
9H-Purin-6-amine, 9-(2-deoxy-3,5-di-O-phosphono-α-D-erythro-pentofuranosyl)-N-methyl-, sodium salt (1:4)
Biological Activity
[Description]:
MRS 2179 is a potent, selective, competitive P2Y1 receptor antagonist with Kb of 100 nM; displays no appreciable activity at P2Y2, P2Y4, or P2Y6 receptors (>30 uM); inhibits ADP-induced platelet shape change, aggregation and Ca2+ rise but has no effect on ADP-induced inhibition of adenylyl cyclase; decreases platelet count in mice.
[References]
References 1. Moro S, et al. J Med Chem. 1998 Apr 23;41(9):1456-66. 2. Baurand A, et al. Eur J Pharmacol. 2001 Feb 2;412(3):213-21. 3. Léon C, et al. Circulation. 2001 Feb 6;103(5):718-23. View Related Products by Target P2Y Receptor
Chemical & Physical Properties
[ Molecular Formula ]:
C11H13N5O9P2Na4
[ Molecular Weight ]:
513.156
[ Exact Mass ]:
512.977905