BRD-7880
Names
[ CAS No. ]:
1456542-69-0
[ Name ]:
BRD-7880
Biological Activity
[Description]:
A potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively, with less activity against Aurora A (IC50>2 uM); is far more selective than tozasertib (VX-680), substantially inhibiting (to < 25% control activity) only AURKB and AURKC in a panel of 308 kinases.
[References]
References 1. Yu C, et al. Nat Biotechnol. 2016 Apr;34(4):419-23. View Related Products by Target Aurora Kinase
Chemical & Physical Properties
[ Molecular Formula ]:
C32H38N4O7
[ Molecular Weight ]:
590.677