BRD-7880

Names

[ Name ]:
BRD-7880

Biological Activity

[Description]:

A potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively, with less activity against Aurora A (IC50>2 uM); is far more selective than tozasertib (VX-680), substantially inhibiting (to < 25% control activity) only AURKB and AURKC in a panel of 308 kinases.

[References]

References 1. Yu C, et al. Nat Biotechnol. 2016 Apr;34(4):419-23. View Related Products by Target Aurora Kinase

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₈N₄O₇

[ Molecular Weight ]:
590.677

Related Compounds

BRD-IN-26
brd-in-3
BRD 8184
BRD 8430
BRD 8899
BRD 0476
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
N-(2-Methoxyethyl)-7-(pyridin-2-YL)-1,6-naphthyridin-5-amine
[(2R)-1-aminopropan-2-yl](ethyl)amine
N1-(furan-2-ylmethyl)-N2-((1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)methyl)oxalamide
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
N-([2,3'-bipyridin]-4-ylmethyl)-3-(3-methylthiophen-2-yl)propanamide