NOC-5

Names

[ Name ]:
NOC-5

[Synonym ]:
N-[3-aminopropyl(propan-2-yl)amino]-N-hydroxynitrous amide
3-(Aminopropyl)-1-hydroxy-3-isopropyl-2-oxo-1-triazene
1-(3-Aminopropyl)-2-hydroxy-1-isopropyl-3-oxotriazane
1-Propanamine, 3-[2-hydroxy-1-(1-methylethyl)-3-oxotriazanyl]-
3-(2-Hydroxy-1-(1-methylethyl)-2-nitrosohydrazino)-1-propanamine
MFCD00274389

Biological Activity

[Description]:

NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

NOC-5 (5-20 μM) in PBS led to a rapid increase in NO release on day one[1]. NOC-5 (100 μM, 24 h) activates only caspase-3; an increase in caspase-3 activity occurred after NO donor treatment: 1.62 (1.57-1.66) (P < 0.05). NOC-5 has pro-apoptotic action in Jurkat cells, but at the same time increased the level of anti-apoptotic proteins[2].

[References]

[1]. Sophie A Bradley, et al. Characterisation and comparison of temporal release profiles of nitric oxide generating donors. J Neurosci Methods. 2015 Apr 30;245:116-24.

[2]. Elena G Starikova, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38(7):799-802.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
270.1±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₁₆N₄O₂

[ Molecular Weight ]:
176.217

[ Flash Point ]:
117.2±27.9 °C

[ Exact Mass ]:
176.127319

[ PSA ]:
90.60000

[ LogP ]:
0.02

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.525

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26;S36

[ RIDADR ]:
NONH for all modes of transport

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