MAHMA NONOate

Names

[ Name ]:
MAHMA NONOate

[Synonym ]:
MFCD01310509
METHYLAMINE HEXAMETHYLENE METHYLAMINE NONOATE
noc-9crystalline
2-Hydroxy-1-methyl-1-[6-(methylamino)hexyl]-3-oxotriazane
6-(2-Hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hexanamine NOC-9
1-Hexanamine, 6-(2-hydroxy-1-methyl-3-oxotriazanyl)-N-methyl-
NOC-9
MAHMA/NO

Biological Activity

[Description]:

MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[In Vitro]

MAHMA NONOate (0.1 nM-100 μM) dose-dependently inhibits platelet aggregation induced by either collagen or ADP[1]. MAHMA NONOate shows inhibitory effects to pulmonary artery and platelet aggregation with log IC50 values of 7.18 and 6.16, respectively[1].

[In Vivo]

MAHMA NONOate (0.3-10 nmol/kg/min; i.v. once) shows both platelet inhibitory and vasodepressor effects in vivo[2]. Animal Model: Male Wistar rats anaesthetised with pentobarbitone[2] Dosage: 0.3-10 nmol/kg/min Administration: Intravenous injection; 0.3-10 nmol/kg/min once Result: Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
301.7±44.0 °C at 760 mmHg

[ Melting Point ]:
102-108ºC

[ Molecular Formula ]:
C₈H₂₀N₄O₂

[ Molecular Weight ]:
204.270

[ Flash Point ]:
136.3±28.4 °C

[ Exact Mass ]:
204.158630

[ PSA ]:
68.17000

[ LogP ]:
0.44

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.503

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

Articles

Salmonella enterica biofilm-mediated dispersal by nitric oxide donors in association with cellulose nanocrystal hydrogels.

AMB Express 5 , 28, (2015)

Protected by extracellular polymers, microbes within biofilms are significantly more resistant to disinfectants. Current research has been instrumental in identifying nitric oxide donors and hydrogels...

Organelle-Specific Nitric Oxide Detection in Living Cells via HaloTag Protein Labeling.

PLoS ONE 10 , e0123986, (2015)

Nitric oxide (NO) is a membrane-permeable signaling molecule that is constantly produced, transferred, and consumed in vivo. NO participates and plays important roles in multiple biological processes....

Effect of nitric oxide on VnfA, a transcriptional activator of VFe-nitrogenase in Azotobacter vinelandii.

J. Biochem. 157 , 365-75, (2015)

The transcriptional activator, VnfA, is necessary for the expression of the structural genes encoding vanadium-dependent nitrogenase in Azotobacter vinelandii. We have previously reported that VnfA ha...