Cyclazosin hydrochloride

Names

[ Name ]:
Cyclazosin hydrochloride

[Synonym ]:
Cyclazosin hydrochloride
Methanone, [(4aR,8aS)-4-(4-amino-6,7-dimethoxy-2-quinazolinyl)octahydro-1(2H)-quinoxalinyl]-2-furanyl-, hydrochloride (1:1)
[(4aR,8aS)-4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)octahydro-1(2H)-quinoxalinyl](2-furyl)methanone hydrochloride (1:1)
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) decahydroquinoxaline
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone,hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
691.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₈ClN₅O₄

[ Molecular Weight ]:
473.953

[ Flash Point ]:
371.7ºC

[ Exact Mass ]:
473.182983

[ PSA ]:
106.95000

[ LogP ]:
4.48190

[ Appearance of Characters ]:
solid | white

[ Vapour Pressure ]:
2.43E-19mmHg at 25°C

[ Water Solubility ]:
H2O: 1.8 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist.

J. Med. Chem. 39 , 4602, (1996)

The enantiomers of [4-(4-amino-6, 7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-1-yl]-fu ran- 2-ylmethanone (cyclazosin, 1) were synthesized from the chiral furan-2-yl(cis-octahydroquinoxalin-1-...

Receptor binding profile of cyclazosin, a new alpha 1B-adrenoceptor antagonist.

Eur. J. Pharmacol. 287 , 13-16, (1995)

The binding profile of cyclazosin, a new prazosin-related alpha 1-adrenoceptor antagonist, at alpha 1-, alpha 2-adrenoceptors, dopamine D2 and 5-HT1A receptors was compared to that of 5-methylurapidil...