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MC-SN38

Names

[ CAS No. ]:
1473403-87-0

[ Name ]:
MC-SN38

Biological Activity

[Description]:

MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56.

[2]. Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51(16):4187-4191.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H31N3O8

[ Molecular Weight ]:
585.60

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds