ABP 1

Names

[ Name ]:
ABP 1

Biological Activity

[Description]:

A nonselective inhibitor of UBL protein-activating E1 enzymes that forms covalent adducts with UBL proteins SUMO1, ubiquitin, Nedd8, ISG15, and GABARAP in the presence of ATP and E1 enzymes in vitro; covalently labels not only for canonical E1s (UBE1, SAE1/SAE2, NAE1/UBA3, UBE1L, and UBA6) but also for noncanonical E1s (UBA5 and ATG7).

[References]

References 1. An H, et al. J Am Chem Soc. 2013 Nov 13;135(45):16948-62. 2. An H, et al. Chem Sci. 2015 Sep 1;6(9):5235-5245. View Related Products by Target Ubiquitin-activating Enzyme (E1)

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₆N₆O₆S

[ Molecular Weight ]:
384.367

Related Compounds

ABP 688
2-[(6-oxo-1H-pyridin-3-yl)methylamino]-N-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide
2-[1-(2-hydroxy-3,5-dimethylphenyl)cyclohexyl]-4,6-dimethylphenol
3-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)norbornan-2-one
3-[1-(2,5-dimethylthiophen-3-yl)octadecyl]-4-propan-2-ylideneoxolane-2,5-dione
hex-1-enyl(diphenyl)phosphane
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine