<Suppliers Price>

Sacituzumab govitecan

Names

[ CAS No. ]:
1491917-83-9

[ Name ]:
Sacituzumab govitecan

[Synonym ]:
hRS7-SN38
IMMU-132
IMMU 132
N-[4-(-Carboxycyclohexylmethyl)]maleimide

Biological Activity

[Description]:

Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vivo]

Sacituzumab govitecan (IMMU-132) (17.5 mg/kg; twice weekly for 4 weeks) results in significant anti-tumor effects in mice bearing human gastric cancer xenografts[1].

[References]

[1]. Cardillo TM, et al. Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody-Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers. Bioconjug Chem. 2015 May 20;26(5):919-31.

Chemical & Physical Properties

[ Molecular Formula ]:
C76H104N12O24S

[ Molecular Weight ]:
1601.77000

[ Exact Mass ]:
1600.70000

[ PSA ]:
499.15000

[ LogP ]:
5.09770

[ Storage condition ]:
2-8°C

Related Compounds