2-methyl-2-phenylsuccinimide

Names

[ Name ]:
2-methyl-2-phenylsuccinimide

[Synonym ]:
3-Phenyl-3-methylpyrrolidine-2,5-dione
3-Methyl-3-phenyl-pyrrolidin-2,5-dion
n-desmethylmethsuximide
A-METHYL-A-PHENYLSUCCINIMIDE
Mesuximide,M(nor-)
EINECS 216-091-7
3-Methyl-3-phenyl-2,5-pyrrolidinedione
MFCD00005496
3-methyl-3-phenylpyrrolidine-2,5-dione
Normesuximide
N-Demethylmethsuximide
2-methyl-2-phenylsuccinimide
3-phenyl-3-methyl succinic imide
(3RS)-3-Methyl-3-phenylsuccinimid

Chemical & Physical Properties

[ Density]:
1.179g/cm3

[ Boiling Point ]:
371.1ºC at 760mmHg

[ Melting Point ]:
83-85ºC(lit.)

[ Molecular Formula ]:
C₁₁H₁₁NO₂

[ Molecular Weight ]:
189.21100

[ Flash Point ]:
165.3ºC

[ Exact Mass ]:
189.07900

[ PSA ]:
46.17000

[ LogP ]:
1.31960

[ Vapour Pressure ]:
1.06E-05mmHg at 25°C

[ Index of Refraction ]:
1.55

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2925190090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Anticonvulsants Based on the α-Substituted Amide Group Pharmacophore Bind to and Inhibit Function of Neuronal Nicotinic Acetylcholine Receptors.

ACS Chem. Neurosci. 7 , 316-26, (2016)

Although the antiepileptic properties of α-substituted lactams, acetamides, and cyclic imides have been known for over 60 years, the mechanism by which they act remains unclear. I report here that the...

Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction.

Br. J. Pharmacol. 100(4) , 800-6, (1990)

1. Succinimide derivatives can be either convulsant (tetramethylsuccinimide (TMS)), or anticonvulsant (ethosuximide (ES); alpha-methyl-alpha-phenylsuccinimide (MPS)). ES, an anticonvulsant succinimide...

Block of cloned human T-type calcium channels by succinimide antiepileptic drugs.

Mol. Pharmacol. 60(5) , 1121-32, (2001)

Inhibition of T-type Ca(2+) channels has been proposed to play a role in the therapeutic action of succinimide antiepileptic drugs. Despite the widespread acceptance of this hypothesis, recent studies...